Clinical trials :
xxviii, 886 pages : illustrations ; 27 cm. - (Wiley series in probability and statistics ) Content notes : 1. Preliminaries --
2. Clinical trials as research --
3. Why clinical trials are ethical --
4. Contexts for clinical trials --
5. Measurement --
6. Random error and bias --
7. Statistical perspectives --
8. Experimental designs in clinical trials --
9. The trial cohort --
10. Development paradigms --
11. Translational clinical trials --
12. Early development and dose-finding designs --
13. Middle development --
14. Comparative trials --
15. Adaptive design features --
16. Sample size and power --
17. Treatment allocation --
18. Treatment effects monitoring --
19. Counting subjects and events --
20. Estimating clinical effects --
21. Prognostic factor analyses --
22. Factorial designs --
23. Crossover designs --
24. Meta-analyses --
25. Reporting and authorship --
26. Misconduct and fraud in clinical research.
Appendices.
