Planning and Analyzing Clinical Trials with Composite Endpoints

519.5

Rauch, Geraldine. Planning and Analyzing Clinical Trials with Composite Endpoints by Geraldine Rauch, Svenja Schüler, Meinhard Kieser. -
XVI, 255 p. 9 illus., 2 illus. in color. online resource. - (Springer Series in Pharmaceutical Statistics, ) Content notes : Preface -- Contents -- Part I General Introduction to Composite Endpoints -- 1 Definition and Rationale -- 2 Challenges of Composite Endpoints -- 3 Guideline View - Recommendations and Requirements -- 4 Clinical Trial Examples -- Part II Confirmatory Test Problem for a Single (Composite) Endpoint -- 5 The Single-Stage Design -- 6 Group-Sequential and Adaptive Designs -- 7 Related Software Code -- Part III Confirmatory Multiple Test Problem -- 8 Correlation Between Test Statistics -- 9 The Single-Stage Design -- 10 Group-Sequential and Adaptive Designs -- 11 Related Software Code -- Part IV Confirmatory Test Problem for a Weighted Composite Endpoint -- 12 Weighted Binary Composite Endpoint -- Weighted Time-to-Event Composite Endpoint -- 14 OtherWeighted Effect Measures -- 15 Related Software Code -- Part V Descriptive and Confirmatory Evaluation of the Components -- 16 Descriptive Analysis of the Components -- 17 Supplementary Confirmatory Analyses of the Components -- 18 Related Software Code -- Part VI Illustrating Clinical Trial Examples -- 19 Clinical Trial Examples with Binary (Composite) Endpoints -- 20 Clinical Trial Examples with (Composite) Time-to-Event Endpoints. 9783319737706 * Statistics. Statistical methods. Pharmaceutical technology. Statistics for Life Sciences, Medicine, Health Sciences. Biostatistics. Pharmaceutical Sciences/Technology. * Schüler, Svenja., aut, http://id.loc.gov/vocabulary/relators/autKieser, Meinhard., aut, http://id.loc.gov/vocabulary/relators/aut * Title * Series