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Ribozymes in the gene therapy of cancer [electronic resource] / [edited by] Kevin J. Scanlon, Mohammed Kashani-Sabet.

Contributor(s): Scanlon, Kevin J, 1947- | Kashani-Sabet, Mohammed.
Material type: TextTextSeries: Medical intelligence unit: 4.Publisher: Austin : R.G. Landes Co., c1998Description: 1 online resource (236 p.) : ill.ISBN: 0585417350 (electronic bk.); 9780585417356 (electronic bk.); 1597342475; 9781597342476.Subject(s): Cancer -- Gene therapy | Catalytic RNA -- Therapeutic use | Neoplasms -- therapy | RNA, Catalytic -- therapeutic use | Gene Therapy -- methods | MEDICAL -- Oncology | HEALTH & FITNESS -- Diseases -- CancerGenre/Form: Electronic books.Additional physical formats: Print version:: Ribozymes in the gene therapy of cancer.DDC classification: 616.99/4042 Online resources: EBSCOhost
Contents:
Cover; Inside Cover; Copyright; Table of Contents; Contributors; Foreword; Section I Biochemistry of Ribozymes; CHAPTER 1 The Biochemistry of the Hammerhead Ribozyme; CHAPTER 2 Biochemistry of the Hairpin Ribozyme; CHAPTER 3 Biochemistry of Hepatitis Delta Virus Catalytic RNAs; Section II Expression and Delivery of Ribozymes; CHAPTER 4 Exogenous Delivery of Ribozymes; CHAPTER 5 Novel RNA Motif (Dimeric Minizyme) Capable of Cleaving L6 BCR-ABL Fusion (b2a2) mRNA with High Specificity; CHAPTER 6 Using Ribozymes to Attenuate Gene Expression in Transgenic Mice.
Summary: This book is useful for understanding the essential methods for developing therapeutic applications of ribozymes to disease genes. Detailed protocols are used to design, synthesize and apply ribozymes to knock out disease-associated genes. The primary target for ribozymes is on cancer genes, however, the application can be used for any type of gene.
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Includes bibliographical references and index.

Description based on print version record.

Cover; Inside Cover; Copyright; Table of Contents; Contributors; Foreword; Section I Biochemistry of Ribozymes; CHAPTER 1 The Biochemistry of the Hammerhead Ribozyme; CHAPTER 2 Biochemistry of the Hairpin Ribozyme; CHAPTER 3 Biochemistry of Hepatitis Delta Virus Catalytic RNAs; Section II Expression and Delivery of Ribozymes; CHAPTER 4 Exogenous Delivery of Ribozymes; CHAPTER 5 Novel RNA Motif (Dimeric Minizyme) Capable of Cleaving L6 BCR-ABL Fusion (b2a2) mRNA with High Specificity; CHAPTER 6 Using Ribozymes to Attenuate Gene Expression in Transgenic Mice.

This book is useful for understanding the essential methods for developing therapeutic applications of ribozymes to disease genes. Detailed protocols are used to design, synthesize and apply ribozymes to knock out disease-associated genes. The primary target for ribozymes is on cancer genes, however, the application can be used for any type of gene.

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Ribozymes in the gene therapy of cancer ©1998
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