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Randomised response-adaptive designs in clinical trials / Anthony C. Atkinson and Atanu Biswas.

By: Contributor(s): Material type: TextTextSeries: Monographs on statistics and applied probability ; 130Publication details: Boca Raton : CRC Press, c2014.Description: xvi, 323 p. : illustrations; 24 cmISBN:
  • 9781584886938 (hardcover : alk. paper)
Subject(s): DDC classification:
  • 000SB:615.50724  23 At875
Contents:
1. Adaptive design : controversies and progress -- 2. Randomized balanced sequential treatment allocation -- 3. Response-adaptive designs for binary responses -- 4. Response-adaptive designs for continuous responses -- 5. Response-adaptive designs for longitudinal responses -- 6. Optimum biased-coin designs with covariates -- 7. Optimum response-adaptive designs with covariates -- 8. Optimal response-adaptive designs with constraints -- 9. Adaptive design : further important issues-- A Optimum design-- Bibliography-- Index.
Summary: Response-adaptive designs, which aim to reduce the number of patients receiving inferior treatments, are popular in Phase III clinical trials. This book provides an overview of the research in this area.
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Includes bibliographical references (pages 299-318) and index.

1. Adaptive design : controversies and progress --
2. Randomized balanced sequential treatment allocation --
3. Response-adaptive designs for binary responses --
4. Response-adaptive designs for continuous responses --
5. Response-adaptive designs for longitudinal responses --
6. Optimum biased-coin designs with covariates --
7. Optimum response-adaptive designs with covariates --
8. Optimal response-adaptive designs with constraints --
9. Adaptive design : further important issues--

A Optimum design--
Bibliography--
Index.

Response-adaptive designs, which aim to reduce the number of patients receiving inferior treatments, are popular in Phase III clinical trials. This book provides an overview of the research in this area.

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