Design and analysis of cross-over trials / Byron Jones and Michael G. Kenward.
Material type:
TextSeries: Monographs on statistics and applied probability ; 138.Publication details: Boca Raton : CRC Press, c2015.Edition: 3rd edDescription: xxvi, 412 p. : illustrations ; 25 cmISBN: - 9781439861424 (hardback)
- 000SA.2 23 J76
| Item type | Current library | Call number | Status | Date due | Barcode | Item holds | |
|---|---|---|---|---|---|---|---|
| Books | ISI Library, Kolkata | 000SA.2 J76 (Browse shelf(Opens below)) | Available | 136353 |
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| 000SA.2 Ea13 Fundamentals of statistical experimental design and analysis / | 000SA.2 F294 Optimal design for nonlinear response models / | 000SA.2 G977 Design and analysis of experiments / | 000SA.2 J76 Design and analysis of cross-over trials / | 000SA.2 K32 Design and analysis of experiments | 000SA.2 K32 Design and analysis of experiments | 000SA.2 K32 Design and analysis of experiments |
Includes bibliographical references and index.
1. Introduction --
2. The 2x2 cross-over trial --
3. Higher-order for two treatments --
4. Designing cross-over trials --
5. Analysis of continuous data --
6. Analysis of discrete data --
7. Bioequivalence trials --
8. Case study : phase I dose-response noninferiority trial --
9. Case study : choosing a dose-response model --
10. Case study : conditional power --
11. Case study : proof of concept trial with sample size re-estimation --
12. Case study : blinded sample size re-estimation in a bioequivalence study --
13. Case study : unblinded sample size re-estimation in a bioequivalence study that has a group sequential design --
14. Case study : various methods for an unblinded sample size re-estimation in a bioequivalence study--
Appendix--
Bibliography--
Index.
This edition has been updated with recent references and new material on analysis of small trials, analysis of baseline measurements, bioequivalence, cross-over trials in early phase drug development, and adaptive cross-over trials. The book includes numerous real examples, including some new data sets to illustrate the methods described, with SAS code available for their implementation.
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