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Modern adaptive randomized clinical trials : statistical and practical aspects / [edited by] Oleksandr Sverdlov.

Contributor(s): Material type: TextTextSeries: Chapman & Hall/CRC biostatistics seriesPublication details: Boca Raton : CRC Press, c2016.Description: xvii, 514 p. : illustrations, 24 cmISBN:
  • 9781482239881 (hardcover : alk. paper)
Subject(s): DDC classification:
  • 000SB:615.58 23 Sv968
Contents:
1. An overview of adaptive randomization designs in clinical trials / Oleksandr Sverdlov -- 2. Efron's biased coin design revisited : statistical properties randomization-based inference and sequential monitoring / Victoria Plamadeala -- 3. Adaptive biased coins : achieving better balance without compromising randomness / Alessandro Baldi Antognini and Maroussa Zagoraiou -- 4. Brick tunnel and wide brick tunnel randomization for studies with unequal allocation / Olga M. Kuznetsova and Yevgen Tymofyeyev -- 5. Development of novel covariate-adaptive randomization designs / Wenle Zhao -- 6. Optimal model-based covariate-adaptive randomization designs / Anthony Atkinson -- 7. Statistical inference following covariate-adaptive randomization : recent advances / D. Stephen Coad -- 8. Covariate-adaptive randomization with unequal allocation / Olga M. Kuznetsova and Yevgen Tymofyeyev -- 9. Optimal allocation designs for a multi-arm multi-objective clinical trial / David Azriel -- 10. Response-adaptive randomization : an overview of designs and asymptotic theory / Li-Xin Zhang -- 11. Statistical inference following response-adaptive randomization / Yanqing Yi and Xikui Wang -- 12. Sample size re-estimation in adaptively randomized clinical trials with missing data / Ruitao Lin and Guosheng Yin -- 13. Some caveats for outcome adaptive randomization in clinical trials / Peter F. Thall, Patricia S. Fox, and J. Kyle Wathen -- 14. Ecient and ethical adaptive clinical trial designs to detect treatment-covariate interaction / Seung Won Hyun, Tao Huang, and Hongjian Zhu -- 15. Longitudinal covariate-adjusted response/adaptive randomization : impact of missing data / Tao Huang and Hongjian Zhu -- 16. Targeted covariate-adjusted response/adaptive Lasso-based randomized controlled trials / Antoine Chambaz, Mark J. van der Laan and Wenjing Zheng -- 17. Covariate-balanced Bayesian adaptive randomization : achieving trade off between inferential and ethical goals in small and moderate size trials / Ying Yuan and Jing Ning -- 18. Multi-arm multi-stage designs for clinical trials with treatment selection / James Wason -- 19. Sequential elimination in multi-arm selection trials / Christina Yap, Xuejing Lin, and Ying Kuen K. Cheung -- 20. Accounting for parameter uncertainty in two-stage designs for phase II dose-response studies / Emma McCallum and Bjorn Bornkamp -- 21. A single pivotal adaptive trial in infants with proliferating hemangioma : rationale, design challenges, experience and recommendations / Stephane Heritier, Caroline C. Morgan-Bouniol, Serigne N. Lô, Stephanie Gautier, and Jean Jacques Voisard -- 22. Practical implementation of dose-response adaptive trials / Tom Parke and Martin Kimber -- 23. Statistical monitoring of data in response-adaptive randomized clinical trials / Paul Gallo.
Summary: Modern Adaptive Randomized Clinical Trials: Statistical and Practical Aspects answers these questions and more. From novel designs to cutting-edge applications, this book presents several new and key developments in adaptive randomization. It also offers a fresh and critical look at a number of already-classical topics. Featuring contributions from statisticians, clinical trialists, and subject-matter experts in academia and the pharmaceutical industry
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Includes bibliographical references and index.

1. An overview of adaptive randomization designs in clinical trials / Oleksandr Sverdlov --
2. Efron's biased coin design revisited : statistical properties randomization-based inference and sequential monitoring / Victoria Plamadeala --
3. Adaptive biased coins : achieving better balance without compromising randomness / Alessandro Baldi Antognini and Maroussa Zagoraiou --
4. Brick tunnel and wide brick tunnel randomization for studies with unequal allocation / Olga M. Kuznetsova and Yevgen Tymofyeyev --
5. Development of novel covariate-adaptive randomization designs / Wenle Zhao --
6. Optimal model-based covariate-adaptive randomization designs / Anthony Atkinson --
7. Statistical inference following covariate-adaptive randomization : recent advances / D. Stephen Coad --
8. Covariate-adaptive randomization with unequal allocation / Olga M. Kuznetsova and Yevgen Tymofyeyev --
9. Optimal allocation designs for a multi-arm multi-objective clinical trial / David Azriel --
10. Response-adaptive randomization : an overview of designs and asymptotic theory / Li-Xin Zhang --
11. Statistical inference following response-adaptive randomization / Yanqing Yi and Xikui Wang --
12. Sample size re-estimation in adaptively randomized clinical trials with missing data / Ruitao Lin and Guosheng Yin --
13. Some caveats for outcome adaptive randomization in clinical trials / Peter F. Thall, Patricia S. Fox, and J. Kyle Wathen --
14. Ecient and ethical adaptive clinical trial designs to detect treatment-covariate interaction / Seung Won Hyun, Tao Huang, and Hongjian Zhu --
15. Longitudinal covariate-adjusted response/adaptive randomization : impact of missing data / Tao Huang and Hongjian Zhu --
16. Targeted covariate-adjusted response/adaptive Lasso-based randomized controlled trials / Antoine Chambaz, Mark J. van der Laan and Wenjing Zheng --
17. Covariate-balanced Bayesian adaptive randomization : achieving trade off between inferential and ethical goals in small and moderate size trials / Ying Yuan and Jing Ning --
18. Multi-arm multi-stage designs for clinical trials with treatment selection / James Wason --
19. Sequential elimination in multi-arm selection trials / Christina Yap, Xuejing Lin, and Ying Kuen K. Cheung --
20. Accounting for parameter uncertainty in two-stage designs for phase II dose-response studies / Emma McCallum and Bjorn Bornkamp --
21. A single pivotal adaptive trial in infants with proliferating hemangioma : rationale, design challenges, experience and recommendations / Stephane Heritier, Caroline C. Morgan-Bouniol, Serigne N. Lô, Stephanie Gautier, and Jean Jacques Voisard --
22. Practical implementation of dose-response adaptive trials / Tom Parke and Martin Kimber --
23. Statistical monitoring of data in response-adaptive randomized clinical trials / Paul Gallo.

Modern Adaptive Randomized Clinical Trials: Statistical and Practical Aspects answers these questions and more. From novel designs to cutting-edge applications, this book presents several new and key developments in adaptive randomization. It also offers a fresh and critical look at a number of already-classical topics. Featuring contributions from statisticians, clinical trialists, and subject-matter experts in academia and the pharmaceutical industry

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