Sample size calculations in clinical research/ Shein-Chung Chow, Jun Shao, Hansheng Wang and Yuliya Lokhnygina eds.

"A CRC title, part of the Taylor & Francis imprint, a member of the Taylor & Francis Group, the academic division of T&F Informa plc."

Includes bibliographical references and index

Preface -- Introduction -- Considerations Prior to Sample Size Calculation -- Comparing Means -- Large Sample Tests for Proportions -- Exact Tests for Proportions -- Tests for Goodness-of-Fit and Contingency Tables -- Comparing Time-to-Event Data -- Group Sequential methods -- Comparing Variabilities -- Bioequivalence Testing -- Dose-response Studies -- Microarray Studies -- Bayesian sample Size Calculation -- Nonparametrics -- Sample Size Calculations for Cluster Randomized trials -- Test for Homogeneity of Two Zero-Inflated Poisson Population -- Sample Size for Clinical Trials with Extremely Low Incidence Rate -- Sample Size Calculation for Two-Adaptive Trial design -- Simulation-Based Sample Size and Power Analysis -- Sample Size calculation in Other Areas -- Bibliography -- Index

This book focuses on an integral part of pharmaceutical development, Sample Size Calculations in Clinical Research, Second Edition presents statistical procedures for performing sample size calculations during various phases of clinical research and development. It provides sample size formulas and procedures for testing equality, non inferiority/superiority, and equivalence.