TY  - BOOK
AU  - Grady,Christine
TI  - The search for an AIDS vaccine: ethical issues in the development and testing of a preventive HIV vaccine 
SN  - 0253326192
AV  - RA644.A25 G73 1995
U1  - 174/.2 20
PY  - 1995///
CY  - Bloomington
PB  - Indiana University Press
KW  - AIDS (Disease)
KW  - Vaccination
KW  - Moral and ethical aspects
KW  - Prevention
KW  - Research
KW  - Clinical trials
KW  - AIDS
KW  - gtt
KW  - Vaccins
KW  - Medische ethiek
KW  - AIDS Vaccines
KW  - HIV Infections
KW  - prevention & control
KW  - Clinical Trials as Topic
KW  - Ethics, Medical
KW  - Vaccins contre le SIDA
KW  - fmesh
KW  - HIV, infections x Prévention et contrôle
KW  - Essais cliniques comme sujet
KW  - Éthique des médecins
KW  - Recherche
N1  - Includes bibliographical references (p. [163]-185) and index; 1. Vaccines and Their Development: Historical, Social, and Scientific Perspectives -- 2. Human-Subjects Research and the Regulation of Drugs and Biologicals -- 3. Human-Subjects Research and HIV Vaccines -- 4. The State of HIV Vaccine Science -- 5. Planning Phase III HIV Vaccine Efficacy Trials -- 6. Summary
N2  - Efforts to halt the spread of AIDS have failed so far, and the creation of a vaccine seems the best hope for controlling the disease. Yet the process of developing and testing an HIV vaccine raises a host of difficult ethical issues. These concerns are the focus of this timely and important book; Describing the role of vaccines in controlling infectious disease, this study surveys the guidelines, regulations, and attitudes concerning human-subjects research. There is current information on the state of HIV research and the challenges facing scientists. Vaccine research differs considerably from drug research, and Grady explores the current wisdom governing research with human subjects. Proposing a model for the ethical conduct of vaccine research in general, this book applies it to the complex case of an HIV vaccine. Clinical trials are already ongoing, and the next step, field trials to determine efficacy, involves another set of issues - and a call for new strategies for ethical conduct. The Search for an AIDS Vaccine is essential reading for everyone interested in ethics and the conduct of HIV vaccine research
UR  - http://www.archive.org/details/searchforaidsvac00grad
UR  - http://www.openlibrary.org/books/OL1110199M
ER  -