TY  - BOOK
AU  - Brown,Sarah R.
AU  - Gregory,Walter M.
AU  - Twelves,Chris
AU  - Brown,Julia
TI  - Practical guide to designing phase II trials in oncology
T2  - Statistics in practice
SN  - 9781118570906 (hardback)
U1  - 000SB:616.994061 23
PY  - 2014///
CY  - Chichester
PB  - John Wiley
KW  - Clinical Trials, Phase II as Topic
KW  - Antineoplastic Agents
KW  - Therapeutic use
KW  - Drug Evaluation
KW  - methods
KW  - Neoplasms
KW  - drug therapy
N1  - Includes bibliographical references and index; 1. Introduction--
2. Key points for consideration--
3. Designs for single experimental therapies with a single arm--
4. Designs for single experimental therapies including randomization--
5. Treatment selection designs--
6. Designs incorporating toxicity as a primary outcome--
7. Designs evaluating targeted subgroups--
8. 'Chemo-radio-sensitisation' in dead and neck cancer--
9. Combination chemotherapy in second-line treatment of non-small cell lung cancer--
10. Selection by biomarker in prostate cancer--
11. Dose selection in advanced multiple myeloma--
12. Targeted therapy for advanced colorectal cancer--
13. Phase II oncology trials: perspective from industry--
References--
Index
N2  - "Choosing Your Phase II Trial Design provides an overview to clinical trial researchers of the steps involved in designing a phase II trial and provides a way to identify a range of optimal designs. Providing a practical guide containing the information needed to make crucial decisions regarding phase II trial designs, it sets forth specific points for consideration between the statistician and clinician when designing a phase II trial, including issues such as how the treatment works, choice of outcome measure and randomisation. A detailed library of trial designs is featured along with examples and case studies accompanied by illustrations using a flow diagram, highlighting the choices made for each key point throughout the process. For those new to trial design, the book provides an introduction to the concepts behind informed decision making in phase II trials, offering a unique and practical learning tool. For those familiar with phase II trial design, the reader will benefit from exposure to new, less familiar trial designs, providing alternative options to those which the reader may not have previously used"--Provided by publisher
ER  -