TY  - BOOK
AU  - Jones,Byron
AU  - Kenward,Michael G.
TI  - Design and analysis of cross-over trials
T2  - Monographs on statistics and applied probability
SN  - 9781439861424 (hardback)
U1  - 000SA.2 23
PY  - 2015///
CY  - Boca Raton
PB  - CRC Press
KW  - Crossover trials
KW  - Design of experiments
N1  - Includes bibliographical references and index; 1. Introduction --
 2. The 2x2 cross-over trial --
 3. Higher-order for two treatments --
 4. Designing cross-over trials --
 5. Analysis of continuous data --
 6. Analysis of discrete data --
 7. Bioequivalence trials --
 8. Case study : phase I dose-response noninferiority trial --
 9. Case study : choosing a dose-response model --
 10. Case study : conditional power --
 11. Case study : proof of concept trial with sample size re-estimation --
 12. Case study : blinded sample size re-estimation in a bioequivalence study --
 13. Case study : unblinded sample size re-estimation in a bioequivalence study that has a group sequential design --
 14. Case study : various methods for an unblinded sample size re-estimation in a bioequivalence study--
Appendix--
Bibliography--
Index
N2  - This edition has been updated with recent references and new material on analysis of small trials, analysis of baseline measurements, bioequivalence, cross-over trials in early phase drug development, and adaptive cross-over trials. The book includes numerous real examples, including some new data sets to illustrate the methods described, with SAS code available for their implementation
ER  -