TY - BOOK AU - Wang,Jixian TI - Exposure-response modeling: methods and practical implementation T2 - Chapman & Hall/CRC biostatistics series SN - 9781466573208 (hardcover : acidfree paper) U1 - 000SB:615.19 23 PY - 2016/// CY - Boca Raton PB - CRC Press, KW - Exposure therapy KW - Statistical methods. KW - Drug development KW - Biometry. N1 - Includes bibliographical references and index; 1. Introduction -- 2. Basic exposure and exposure-response models -- 3. Dose-exposure and exposure-response models for longitudinal data -- 4. Sequential and simultaneous exposure-response modeling -- 5. Exposure-risk modeling for time-to-event data -- 6. Modeling dynamic exposure-response relationships -- 7. Bayesian modeling and model-based decision analysis -- 8. Confounding bias and causal inference in exposure-response modeling -- 9. Dose-response relationship, dose determination, and adjustment -- 10. Implementation using software -- Appendix N2 - Discover the Latest Statistical Approaches for Modeling Exposure-Response RelationshipsWritten by an applied statistician with extensive practical experience in drug development, Exposure-Response Modeling: Methods and Practical Implementation explores a wide range of topics in exposure-response modeling, from traditional pharmacokinetic-pharmacodynamic (PKPD) modeling to other areas in drug development and beyond. It incorporates numerous examples and software programs for implementing novel methods.The book describes using measurement error models to treat sequential modeling, fitting models. ER -