TY  - BOOK
AU  - Matsui,Shigeyuki
AU  - Buyse,Marc
AU  - Simon,Richard
TI  - Design and analysis of clinical trials for predictive medicine
T2  - Chapman & Hall/CRC biostatistics series
SN  - 9781466558151
U1  - 000SB:615.5 23
PY  - 2015///
CY  - Boca Raton
PB  - CRC Press
KW  - Clinical trials
KW  - Statistical methods
KW  - Biochemical markers
KW  - Genetic markers
N1  - Includes bibliographical references and index; Section I. Introductory overview --
Section II. Early clinical trials using biomarkers --
Section III. Phase III randomized clinical trials using biomarkers --
Section IV. Analysis of high-dimensional data and genomic signature developments --
Section V. Randomized trials with biomarker development and validation --Section VI. Evaluation of surrogate biomarkers
N2  - This book is one of the first attempts to contribute to this evolution by laying a foundation for the use of appropriate statistical designs and methods in future clinical trials for predictive medicine. It is a useful resource for clinical biostatisticians, researchers focusing on predictive medicine, clinical investigators, translational scientists, and graduate biostatistics students.

ER  -