TY - BOOK AU - Emmert-Streib,Frank AU - Dehmer,Matthias TI - Medical biostatistics for complex diseases SN - 9783527325856 U1 - 000SB:614.4 23 PY - 2010/// CY - Weinheim PB - Wiley-Blackwell KW - Epidemiology KW - Statistical methods N1 - Includes bibliographical references and index; Part I General biological and statistical basics -- 1. The Biology of MYC in health and disease: a high altitude view -- 2. Cancer stem cells: finding and capping the roots of cancer -- 3. Multiple testing methods -- Part II Statistical and computational analysis methods -- 4. Making mountains out of molehills: moving from single gene to pathway based models of colon cancer progression -- 5. Gene-set expression analysis: challenges and tools -- 6. Multivariate analysis of microarray data using Hotelling's T² test -- 7. Interpreting differential coexpression of gene sets -- 8. Multivariate analysis of microarray data: application of MANOVA -- 9. Testing significance of a class of genes -- 10. Differential dependency network analysis to identify topological changes in biological networks -- 11. An Introduction to time-varying connectivity estimation for gene regulatory networks -- 12. A Systems biology approach to construct a cancer-perturbed protein-protein interaction network for apoptosis by means of microarray and database mining -- 13. A New gene expression meta-analysis technique and its application to co-analyze three independent lung cancer datasets -- 14. Kernel classification methods for cancer microarray data -- 15. Predicting cancer survival using expression patterns -- 16. Integration of microarray datasets -- 17. Model averaging for biological networks with prior information N2 - A collection of highly valuable statistical and computational approaches designed for developing powerful methods to analyze large-scale high-throughput data derived from studies of complex diseases. Such diseases include cancer and cardiovascular disease, and constitute the major health challenges in industrialized countries. ER -