000			01853cam a2200253 i 4500
001			138272
003			ISI Library, Kolkata
005			20180411124226.0
008			161122s2017 njua b 001 0 eng
020			_a9781118959206
040			_aISI Library
082	0	4	_a000SB:610.72 _223 _bP581
100	1		_aPiantadosi, Steven, _eauthor
245	1	0	_aClinical trials : _ba methodologic perspective / _cSteven Piantadosi.
250			_aThird edition.
260			_aHoboken, NJ : _bJohn Wiley & Sons, _c©2017.
300			_axxviii, 886 pages : _billustrations ; _c27 cm.
490	0		_aWiley series in probability and statistics
504			_aIncludes bibliographical references and index.
505	0		_a1. Preliminaries -- 2. Clinical trials as research -- 3. Why clinical trials are ethical -- 4. Contexts for clinical trials -- 5. Measurement -- 6. Random error and bias -- 7. Statistical perspectives -- 8. Experimental designs in clinical trials -- 9. The trial cohort -- 10. Development paradigms -- 11. Translational clinical trials -- 12. Early development and dose-finding designs -- 13. Middle development -- 14. Comparative trials -- 15. Adaptive design features -- 16. Sample size and power -- 17. Treatment allocation -- 18. Treatment effects monitoring -- 19. Counting subjects and events -- 20. Estimating clinical effects -- 21. Prognostic factor analyses -- 22. Factorial designs -- 23. Crossover designs -- 24. Meta-analyses -- 25. Reporting and authorship -- 26. Misconduct and fraud in clinical research. Appendices.
520			_aThis Third Edition of the critically hailed Clinical Trials builds on the text's reputation as a straightforward and authoritative presentation of statistical methods for clinical trials.
650		0	_aClinical trials _xStatistical methods.
942			_2ddc _cBK
999			_c424572 _d424572